瓜蒌薤白桂枝汤对老年冠心病患者的临床观察

目的:探究瓜蒌薤白桂枝汤对老年冠心病患者血脂及NT-proBNP、hs-CRP、Fib水平影响。方法:选取2014年4月至2018年4月西藏民族大学附属医院收治的老年冠心病患者78例作为研究对象,根据就诊顺序编号,按照随机数字表法随机分为对照组和观察组,每组39例。对照组常规西医治疗,观察组在对照组基础上加用瓜蒌薤白桂枝汤治疗,同时治疗4周。观察2组治疗前、完成治疗后血脂、NT-pro BNP、hs-CRP、Fib、WBC、HCY、血流流变学、心脏功能水平变化并比较;完成治疗后进行疗效评价。结果:观察组患者治疗后TC、TG、HDL-C、NT-proBNP、hs-CRP、Fib、WBC、HCY、全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数下降较对照组患者幅度更低,LDL-C、EDD、NEDD、LVEF、LVPFR上升幅度及治疗后临床总有效率较对照组更高(P<0.05)。结论:瓜蒌薤白桂枝汤能降低老年冠心病患者血脂水平,抑制炎性反应,改善冠状动脉血循环,从而提高疗效,改善心功能。     

Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity

Objectives: It is noteworthy that several animal species are known to withstand high levels of radiation, and are exposed to heavy metals but rarely been reported to develop cancer. For example, the scorpion has been used as folk medicine in ancient civilizations of Iran and China, while amphibian skin is known to possess medicinal properties. Here, we elucidated the anti-tumour activity of the scorpion (Uropygi) and frog (Lithobates catesbeianus). Materials and Methods: Animals were procured and their organ lysates and sera were prepared and tested against Michigan Cancer Foundation-7 breast cancer (MCF-7), prostate cancer (PC3), Henrietta Lacks cervical cancer (HeLa), and normal human keratinocyte cells. Exoskeleton, appendages and hepatopancreas were dissected from the scorpion, whereas liver, lungs, heart, oviduct, gastrointestinal tract, gall bladder, kidneys, eggs and sera were collected from frog and organ lysates/sera were prepared. Growth inhibition assays and cytotoxicity assays were performed. Results: Appendages, exoskeleton lysates, and hepatopancreas from scorpion exhibited potent growth inhibition, and cytotoxic effects. Furthermore, lungs, liver, gastrointestinal tract, heart, oviduct, kidneys, eggs, and sera from frog displayed growth inhibition and cytotoxic effects. Conclusion: Organ lysates, sera of scorpion, and amphibians possess anti-tumour activities. This is a worthy area of research as the molecular identity of the active molecule(s) together with their mechanism of action will lead to the rational development of novel anticancer agent(s).     

家庭医生政策执行方式的行为逻辑

本文采用扎根理论,利用2017—2018年上海3家社区卫生服务中心的访谈材料,从执行者行为的微观角度归纳并构建家庭医生如何选择政策执行方式的理论解释。研究归纳了家庭医生相关政策的执行中存在的三类政策执行方式:忠实执行、积极变通和消极变通。这三类政策执行方式因政策与情境契合度(简称契合度)的不同而区分。其中契合度较高时,容易发生忠实执行,即完全忠实于政策设计的执行方式;当政策与情境有不契合时,执行成本升高,出于职责观念和行政压力,执行者首先使用积极变通来降低执行成本,用自由裁量权在操作中对政策作修补和本土化,从而实现政策初衷;消极变通因任务契合度过低且具有强制性而产生,消极变通中出现了目标替代,仅表面应付上级考核指标,降低了执行成本、维护了岗位利益。结论:政策执行方式的行为逻辑可以通过契合度、职责观念、执行成本三个因素得到解释。本文整体、平衡地关注了消极与积极的政策变通,弥补以往研究只关注消极变通的不足;建议应完善决策制度保证基层执行者的决策参与,从而提升决策质量。     

Spontaneous reports of hypersensitivity adverse drug reactions in Portugal: a retrospective analysis

ABSTRACT

Background

Hypersensitivity adverse drug reactions (ADRs) are usually serious, unpredictable, and associated with high morbidity and mortality. This study describes cases of hypersensitivity ADRs spontaneously reported in Central Portugal.     

Implantación de Guías de buenas prácticas en España a través del Programa de Centros Comprometidos con la Excelencia en Cuidados®

The implementation of Best practice guidelines is effective in improving clinical practice and reducing clinical variability. The Best Practice Guidelines of the Ontario Nurses Association have been implemented in Spain since 2012 following the principles of the Canadian programme of the Best Practice Spotlight Organisations® (BPSO®). The Nursing and Healthcare Research Unit (Investén-isciii) coordinates this programme in Spain, having been nominated BPSO Host by the Ontario Nurses Association.Four strategies were followed: translation of the Best Practice Guidelines, dissemination of same and of the programme, implementation of the Best Practice Guidelines and assessment of the results in competitively selected centres, and, finally, the development of sustainability mechanisms.Implementation is based on the theoretical Knowledge to Action model, which establishes a cycle of 6 phases: identification of the problem and training of selected BPSO®; adaptation to the local context; assessment of facilitators and barriers; adaptation and implementation of interventions; monitoring and evaluation of results, and sustainability. Each of these phases incorporate evidence-based elements that promote the effectiveness of implementation, such as the competitive selection of candidates to participate in the programme, selection by the institution of the guidelines to be implemented, leadership by nurses with a multi-professional approach, planning of the process from work structures that are non-vertical but with the support of the institution, the simultaneous use of multiple strategies, ongoing assessment and feedback of results. All of which is mentored and supported by the BPSO Host.There are currently 27 institutions in Spain of different characteristics that implement a total of 20 clinical guidelines. The scope and structure of the programme has recently been extended with regional BPSO Host coordinating centres, which has brought the number of institutions to 36 and the number of implemented clinical guidelines to 22.The programme has had a positive impact on organisations and the system, on care processes and on patient health. This is evidenced by enriched evidence-based professional practice, the promotion of collaborative networking and by improved patient health outcomes and the quality of care provided.     

自拟通络活血方治疗寒凝血瘀型肩周炎的临床效果观察

目的:观察自拟通络活血方治疗寒凝血瘀型肩周炎的临床效果。方法:纳入我院2018年1-12月寒凝血瘀型肩周炎患者共80例为研究对象,将患者的就诊号使用数字表法进行分组,分为观察组与对照组各40例。对照组采取药物联合手法治疗,观察组在对照组基础上使用通络活血方治疗,对比两组患者的临床治疗效果、肩部功能水平、疼痛评分及炎性因子水平差异。结果:观察组的临床治疗效果总体优于对照组,P<0.05;两组患者治疗前的肩功能水平、转化生长因子β1及前列腺素E2水平无明显差异,干预后两组各项指标水平均得到优化,但观察组优于对照组,P<0.05。结论:寒凝血瘀型肩周炎患者使用通络活血方治疗具有更好的临床效果,能够改善肩关节功能与相关炎性因子水平。     

Cyberchondria in First Year Medical Students of Yogyakarta

Abstract

Cyberchondria is a relatively new term addressing health anxiety associated with online information. Research data is scarce, as most instruments measuring anxiety do not consider online behavior an important factor. Medical students are arguably assumed to have frequent health anxieties, i.e. “medical student syndrome.” Moreover, they are exposed to large amounts of information. We aimed to measure the level of cyberchondria severity of first-year medical students. First-year medical students of the regular program at Universitas Gadjah Mada completed self-reported instruments (the Cyberchondria Severity Scale (CSS) and the Beck Anxiety Inventory (BAI)). Cut off was determined using ROC analysis to find the best score that corresponded to BAI cut off of 16. Data were analyzed using chi square and t-tests to analyze any differences between gender. Respondents were 162 students, 54 males and 108 females, with mean age 18.18-year-old ± 0.696. Based on ROC analysis, cut off of 75.5 corresponded with BAI score of 16. Mean CSS score was 70.73 ± 16.292. There was no significant difference of CSS scores between genders. Based on the analysis of individual items, compared to male students, female students more frequently searched for physical symptoms on the Internet, and afterwards, consulted the results with a General Practitioner (GP), discussed with a GP, or went to other specialists; and thus, more frequently required reassurance after online search. In contrast, male students more frequently had difficulty relaxing after searching online for physical symptoms. We concluded that there was no difference of overall cyberchondria severity score, but there were slight but significant differences of online behavior between genders.     

Competition among pharmacies and the typology of services delivered: The Portuguese case

ObjectiveTo analyze the impact of individual and market characteristics (such as competition) on the typology of services delivered by a community pharmacy after a recent Portuguese pro-competitive regulatory change.MethodsIn this paper, market concentration indices are used to identify market competition groups in the sample. These competition groups are then described with regard to the typology of services on offer by pharmacies within the group. Finally, a system of structural equations is estimated to verify if the decision of a pharmacy to offer or not to offer each of the studied pharmaceutical services is affected by local market regulated competition.ResultsIn some cases, pharmacies belonging to different competition groups do not present significant differences in terms of the typology of services on offer, but according to our regressions, it seems that vaccines and medicines administration services, pharmaceutical care programmes and medicines management programmes are more likely to be offered in pharmacies located in higher competitive markets. These are also urban areas, in which there is already easy access to products sold in pharmacies, and to health services in general.ConclusionsAccess to additional pharmacy services may in some cases increase as market competition increases. Thus, pro-competitive regulatory measures may have led to an asymmetric distribution of pharmacy services across the country, favouring more competitive urban marketplaces. If policy-makers are interested in a more symmetrical distribution of pharmacies services all over the country, they are recommended to take action to ensure equitable access to these services.